John Moody
Profiles

John Moody

Associate Professor (Senior Lecturer) in Biochemistry

School of Biological Sciences (Faculty of Science & Environment)

Qualifications

B.Sc. (1st class Hons) Biochemistry, Queen's University, Belfast, 1981

Ph.D. Biology, University of York, 1984

Research interests

Oxidative stress including:
Effects of oxygen in promoting wound healing

Mechanisms of carbon monoxide toxicity

Mechanisms of oxygen toxicity in ciliated trachea

Interaction of oxygen-dependent host defences and antibiotic-resistant pathogens

Mitochondrial and prokaryotic electron transfer complexes

Filamentous gliding bacteria: mechanism of (UV-A+oxygen)- induced killing

Member of School of Biological Sciences Ecotoxicology and Stress Biology Research Centre
Member of Peninsula Medical School Anaethesiology Research Group

Member of Peninsula Oxidative Stress Research Forum

Ph.D. students
as Director of Studies
Lindsey Glew
Anwar Almzaiel
Hanady Al-Shmgani
Angela Cooper
Husam Aljwaid
Rebekah Simpson

as other supervisor
Faculty of Science
Zainab Al-Abady
Louise Belfield
Dokuboba Amachree
Claudio Saez Avaria
Lee Hutt

Other research

Yuan, J., Moody, A.J., Smerdon, G. & Handy, R.D. (2006) Hyperbaric oxygen protects endothelial cells against H2O2-induced DNA damage, Biochem. Soc. Trans.
Rankin, H.V., Moate, R.M., Moody, A.J., MacNaughton, P. & Sneyd, J.R. (2006) Uneven cilial distribution in rat trachea, British Journal of Anaesthesia 96, 281P
Rankin, H.V., Moate, R.M., Moody, A.J., MacNaughton, P., Rahamim, J., Smith, M.E.F. & Sneyd, J.R. (2006) Organ culture of human bronchial explants, British Journal of Anaesthesia 96, 281P-282P
Shaw, F.L., Handy, R.D., Bryson, P., Sneyd R. & Moody, A.J. (2004) Hyperbaric oxygen therapy does not cause oxidative stress in isolated platelets: no effect on superoxide dismutase, catalase, or cellular ATP, Journal of Physiology, PC97, 557P
Shaw, F.L., Handy, R.D., Bryson, P., Sneyd, R. & Moody, A.J. (2004) Hyperbaric oxygen therapy does not cause oxidative stress in isolated platelets: no effect on superoxide dismutase, catalase, or cellular ATP, Comparative Biochemistry and Physiology 137, S15
Handy, R.D., Moody, A.J., Bryson, P., Handy, L.M. & Sneyd, R. (2001) The effect of multiple hyperbaric oxygen treatments on blood function and redox status, Biochem. Soc. Trans. 30: abstract 31
Patel, A., Moody, A.J., Handy, R.D. & Sneyd, R. (2001) Carbon monoxide toxicity in the heart: evidence for ischaemia/reperfusion like injury, Biochem. Soc. Trans. 30: abstract 32
Patel, A.P., Moody, A.J., Handy, R.D. and Sneyd, J.R. (2000) Myoglobin as a biomarker of mitochondrial damage, Toxicology Letters 116 (Suppl. 1), 78

Journals
Articles
Amachree D, Moody AJ & Handy RD 2013 'Comparison of intermittent and continuous exposures to cadmium in the blue mussel, Mytilus edulis: accumulation and sub-lethal physiological effects' Ecotoxicol Environ Saf 95, 19-26 Author Site , DOI
Almzaiel AJ, Billington R, Smerdon G & Moody AJ 2013 'Effects of hyperbaric oxygen treatment on antimicrobial function and apoptosis of differentiated HL-60 (neutrophil-like) cells' Life Sci 93, (2-3) 125-131 Author Site , DOI
Al-Shmgani HS, Moate RM, Macnaughton PD, Sneyd JR & Moody AJ 2013 'Effects of hyperoxia on the permeability of 16HBE14o- cell monolayers--the protective role of antioxidant vitamins E and C' FEBS J 280, (18) 4512-4521 Author Site , DOI
Melatunan S, Calosi P, Rundle SD, Widdicombe S & Moody AJ 2013 'Effects of ocean acidification and elevated temperature on shell plasticity and its energetic basis in an intertidal gastropod' MARINE ECOLOGY PROGRESS SERIES 472, 155-168 Author Site , DOI
Ahmed AR, Moody AJ, Fisher A & Davies SJ 2013 'Growth performance and starch utilization in common carp (Cyprinus carpio L.) in response to dietary chromium chloride supplementation' J Trace Elem Med Biol 27, (1) 45-51 Author Site , DOI
Al-Shmgani HS, Moate RM, Sneyd JR, Macnaughton PD & Moody AJ 2012 'Hyperoxia-induced ciliary loss and oxidative damage in an in vitro bovine model: the protective role of antioxidant vitamins E and C' Biochem Biophys Res Commun 429, (3-4) 191-196 Author Site , DOI
Al-Subiai SN, Arlt VM, Frickers PE, Readman JW, Stolpe B, Lead JR, Moody AJ & Jha AN 2012 'Merging nano-genotoxicology with eco-genotoxicology: an integrated approach to determine interactive genotoxic and sub-lethal toxic effects of C(60) fullerenes and fluoranthene in marine mussels, Mytilus sp' Mutat Res 745, (1-2) 92-103 Author Site , DOI
Nisr RB, Moody AJ & Gilpin ML 2012 'Screening microorganisms for insulin binding reveals binding by Burkholderia multivorans and Burkholderia cenocepacia and novel attachment of insulin to Aeromonas salmonicida via the A-layer' FEMS Microbiol Lett 328, (2) 93-99 Author Site , DOI
Al-Subiai SN, Moody AJ, Mustafa SA & Jha AN 2011 'A multiple biomarker approach to investigate the effects of copper on the marine bivalve mollusc, Mytilus edulis' Ecotoxicol Environ Saf 74, (7) 1913-1920 Author Site , DOI
Askar KA, Kudi AC & Moody AJ 2011 'Comparative analysis of cholinesterase activities in food animals using modified Ellman and Michel assays' Can J Vet Res 75, (4) 261-270 Author Site
Askar KA, Kudi AC & Moody AJ 2011 'Comparison of two storage methods for the analysis of cholinesterase activities in food animals' Enzyme Res 2010, Author Site , DOI
Nisr RB, Russell MA, Chrachri A, Moody AJ & Gilpin ML 2011 'Effects of the microbial secondary metabolites pyrrolnitrin, phenazine and patulin on INS-1 rat pancreatic β-cells' FEMS Immunol Med Microbiol 63, (2) 217-227 Author Site , DOI
Melatunan S, Calosi P, Rundle SD, Moody AJ & Widdicombe S 2011 'Exposure to elevated temperature and Pco(2) reduces respiration rate and energy status in the periwinkle Littorina littorea' Physiol Biochem Zool 84, (6) 583-594 Author Site , DOI
Yuan J, Handy RD, Moody AJ, Smerdon G & Bryson P 2011 'Limited DNA damage in human endothelial cells after hyperbaric oxygen treatment and protection from subsequent hydrogen peroxide exposure' Biochim Biophys Acta 1810, (5) 526-531 Author Site , DOI
Askar KA, Kudi AC & Moody AJ 2011 'Purification of soluble acetylcholinesterase from sheep liver by affinity chromatography' Appl Biochem Biotechnol 165, (1) 336-346 Author Site , DOI
Trevisan R, Mello DF, Fisher AS, Schuwerack PM, Dafre AL & Moody AJ 2011 'Selenium in water enhances antioxidant defenses and protects against copper-induced DNA damage in the blue mussel Mytilus edulis' Aquat Toxicol 101, (1) 64-71 Author Site , DOI
Askar KA, Kudi AC & Moody AJ 2011 'Spontaneous reactivation and aging kinetics of acetylcholinesterase inhibited by dichlorvos and diazinon' JOURNAL OF TOXICOLOGICAL SCIENCES 36, (2) 237-241 Author Site
Waines PL, Moate R, Moody AJ, Allen M & Bradley G 2011 'The effect of material choice on biofilm formation in a model warm water distribution system' Biofouling 27, (10) 1161-1174 Author Site , DOI
Jaeschke BC, Millward GE, Moody AJ & Jha AN 2011 'Tissue-specific incorporation and genotoxicity of different forms of tritium in the marine mussel, Mytilus edulis' Environ Pollut 159, (1) 274-280 Author Site , DOI
Dallas LJ, Shultz AD, Moody AJ, Sloman KA & Danylchuk AJ 2010 'Chemical excretions of angled bonefish Albula vulpes and their potential use as predation cues by juvenile lemon sharks Negaprion brevirostris' J Fish Biol 77, (4) 947-962 Author Site , DOI
Hannam ML, Bamber SD, Galloway TS, John Moody A & Jones MB 2010 'Effects of the model PAH phenanthrene on immune function and oxidative stress in the haemolymph of the temperate scallop Pecten maximus' Chemosphere 78, (7) 779-784 Author Site , DOI
Hannam ML, Bamber SD, Galloway TS, John Moody A & Jones MB 2010 'Functional immune response in Pecten maximus: combined effects of a pathogen-associated molecular pattern and PAH exposure' Fish Shellfish Immunol 28, (1) 249-252 Author Site , DOI
Hannam ML, Bamber SD, Moody AJ, Galloway TS & Jones MB 2010 'Immunotoxicity and oxidative stress in the Arctic scallop Chlamys islandica: effects of acute oil exposure' Ecotoxicol Environ Saf 73, (6) 1440-1448 Author Site , DOI
Al-Subiai SN, Jha AN & Moody AJ 2009 'Contamination of bivalve haemolymph samples by adductor muscle components: implications for biomarker studies' Ecotoxicology 18, (3) 334-342 Author Site , DOI
Shaw FL, Winyard PG, Smerdon GR, Bryson PJ, Moody AJ & Eggleton P 2009 'Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules' Clin Biochem 42, (6) 467-476 Author Site , DOI
Hannam ML, Bamber SD, Moody JA, Galloway TS & Jones MB 2009 'Immune function in the Arctic Scallop, Chlamys islandica, following dispersed oil exposure' Aquat Toxicol 92, (3) 187-194 Author Site , DOI
Yuan J, Handy RD, Moody AJ & Bryson P 2009 'Response of blood vessels in vitro to hyperbaric oxygen (HBO): modulation of VEGF and NO(x) release by external lactate or arginine' Biochim Biophys Acta 1787, (7) 828-834 Author Site , DOI
Munn CB, Marchant HK & Moody AJ 2008 'Defences against oxidative stress in vibrios associated with corals' FEMS Microbiol Lett 281, (1) 58-63 Author Site , DOI
Coleman RA, Ramchunder SJ, Moody AJ & Foggo A 2007 'An enzyme in snail saliva induces herbivore-resistance in a marine alga' FUNCTIONAL ECOLOGY 21, (1) 101-106 Author Site , DOI
Rankin HV, Moody AJ, Moate RM, Macnaughton PD, Rahamim J, Smith ME & Sneyd JR 2007 'Elevated oxygen fraction reduces cilial abundance in explanted human bronchial tissue' Ultrastruct Pathol 31, (5) 339-346 Author Site , DOI
Coleman RA, Ramchunder SJ, Davis KM, Moody AJ & Foggo A 2007 'Herbivore-induced infochemicals influence foraging behaviour in two intertidal predators' Oecologia 151, (3) 454-463 Author Site , DOI
Tran D, Moody AJ, Fisher AS, Foulkes ME & Jha AN 2007 'Protective effects of selenium on mercury-induced DNA damage in mussel haemocytes' Aquat Toxicol 84, (1) 11-18 Author Site , DOI
Yuan J, Handy R, Moody J & Bryson P 2006 'Hyperbaric oxygen therapy does not stimulate production of detectable nitric oxide (NO), vascular endothelial growth factor (VEGF), or damage blood vessels in vitro' Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology 143, (4) S107-S107
Moody AJ & Shaw FL 2006 'Reevaluation of the Greiss reaction: How much of a problem is interference by nicotinamide nucleotides?' Analytical Biochemistry 356, (1) 154-156 , DOI
Shaw FL, Handy RD, Bryson P, Sneyd JR & Moody AJ 2005 'A single exposure to hyperbaric oxygen does not cause oxidative stress in isolated platelets: no effect on superoxide dismutase, catalase, or cellular ATP' Clin Biochem 38, (8) 722-726 Author Site , DOI
Handy RD, Bryson P, Moody AJ, Handy LM & Sneyd JR 2005 'Oxidative metabolism in platelets, platelet aggregation, and hematology in patients undergoing multiple hyperbaric oxygen exposures' Undersea Hyperb Med 32, (5) 327-340 Author Site
Patel AP, Moody AJ, Sneyd JR & Handy RD 2004 'Carbon monoxide exposure in rat heart: evidence for two modes of toxicity' Biochem Biophys Res Commun 321, (1) 241-246 Author Site , DOI
Patel AP, John Moody A, Handy RD & Robert Sneyd J 2003 'Carbon monoxide exposure in rat heart: glutathione depletion is prevented by antioxidants' Biochem Biophys Res Commun 302, (2) 392-396 Author Site
Biggs LF & Moody AJ 2003 'Extreme UV-A sensitivity of the filamentous gliding bacterium Vitreoscilla stercoraria' FEMS Microbiol Lett 224, (1) 73-76 Author Site
White DA, Moody AJ, Serwata RD, Bowen J, Soutar C, Young AJ & Davies SJ 2003 'The degree of carotenoid esterification influences the absorption of astaxanthin in rainbow trout, Oncorhynchus mykiss (Walbaum)' AQUACULTURE NUTRITION 9, (4) 247-251 Author Site , DOI
White DA, Page GI, Swaile J, Moody AJ & Davies SJ 2002 'Effect of esterification on the absorption of astaxanthin in rainbow trout, Oncorhynchus mykiss (Walbaum)' AQUACULTURE RESEARCH 33, (5) 343-350 Author Site , DOI
Moody AJ, Butler CS, Watmough NJ, Thomson AJ & Rich PR 1998 'The reaction of halides with pulsed cytochrome bo from Escherichia coli' Biochem J 331 ( Pt 2), 459-464 Author Site
Moody AJ, Mitchell R, Jeal AE & Rich PR 1997 'Comparison of the ligand-binding properties of native and copper-less cytochromes bo from Escherichia coli' Biochem J 324 ( Pt 3), 743-752 Author Site
Hunter DJ, Moody AJ, Rich PR & Ingledew WJ 1997 'EPR spectroscopy of Escherichia coli cytochrome bo which lacks CuB' FEBS Lett 412, (1) 43-47 Author Site
Moody AJ & Rich PR 1997 'The reaction of halides with cytochrome bo from Escherichia coli' Biochem Soc Trans 25, (1) Author Site
Moody AJ 1996 ''As prepared' forms of fully oxidised haem/Cu terminal oxidases' Biochim Biophys Acta 1276, (1) 6-20 Author Site
Mitchell R, Moody AJ & Rich PR 1995 'Cyanide and carbon monoxide binding to the reduced form of cytochrome bo from Escherichia coli' Biochemistry 34, (23) 7576-7585 Author Site
Moody AJ, Cooper CE, Gennis RB, Rumbley JN & Rich PR 1995 'Interconversion of fast and slow forms of cytochrome bo from Escherichia coli' Biochemistry 34, (20) 6838-6846 Author Site
Moody AJ, Richardson M, Spencer JP, Brandt U & Rich PR 1994 ''CO2-ligated' cytochrome c oxidase: characterization and comparison with the Cl- -ligated enzyme' Biochem J 302 ( Pt 3), 821-826 Author Site
Brown S, Rumbley JN, Moody AJ, Thomas JW, Gennis RB & Rich PR 1994 'Flash photolysis of the carbon monoxide compounds of wild-type and mutant variants of cytochrome bo from Escherichia coli' Biochim Biophys Acta 1183, (3) 521-532 Author Site
Moody AJ & Rich PR 1994 'The reaction of hydrogen peroxide with pulsed cytochrome bo from Escherichia coli' Eur J Biochem 226, (2) 731-737 Author Site
Brown S, Moody AJ, Mitchell R & Rich PR 1993 'Binuclear centre structure of terminal protonmotive oxidases' FEBS Lett 316, (3) 216-223 Author Site
Brown S, Meunier B, Rumbley JN, Lemaire C, Moody AJ, Lemarre P, Blaiseau PL, Madgwick SA, Netter P & Gennis RB 1993 'CO recombination as a probe of the Fe/Cu binuclear centre of terminal protonmotive oxidases' Biochem Soc Trans 21, (4) Author Site
Moody AJ & Rich PR 1993 'Cyanide binding to single-electron-reduced fast cytochrome-c oxidase' Biochem Soc Trans 21 ( Pt 3), (3) Author Site
Moody AJ, Rumbley JN, Gennis RB, Ingledew WJ & Rich PR 1993 'Ligand-binding properties and heterogeneity of cytochrome bo from Escherichia coli' Biochim Biophys Acta 1141, (2-3) 321-329 Author Site
Moody AJ, Spencer JP & Rich PR 1993 'The effects of bicarbonate/carbon dioxide on the near-UV/visible spectrum and ligand binding properties of fast bovine heart cytochrome c oxidase' Biochem Soc Trans 21, (4) Author Site
Rich PR, Moody AJ & Ingledew WJ 1992 'Detection of a near infra-red absorption band of ferrohaem a3 in cytochrome c oxidase' FEBS Lett 305, (3) 171-173 Author Site
Moody AJ, Gennis RB, Hicks DB, Ingledew WJ, Krulwich TA, Rumbley JC & Rich PR 1992 'Ligand binding properties of bacterial oxidases in relation to cytochrome-c oxidase' Biochem Soc Trans 20, (3) Author Site
Moody AJ, Cooper CE & Rich PR 1991 'Characterisation of 'fast' and 'slow' forms of bovine heart cytochrome-c oxidase' Biochim Biophys Acta 1059, (2) 189-207 Author Site
MOODY A & RICH P 1991 'HETEROGENEITY IN FAST CYANIDE-BINDING PREPARATIONS OF CYTOCHROME-C-OXIDASE' BIOCHEMICAL SOCIETY TRANSACTIONS 19, (3) S262-S262 Author Site
Moody AJ, Brandt U & Rich PR 1991 'Single electron reduction of 'slow' and 'fast' cytochrome-c oxidase' FEBS Lett 293, (1-2) 101-105 Author Site
COOPER C, MOODY A, RICH P, WRIGGLESWORTH J & IOANNIDIS N 1991 'THE CYTOCHROME-OXIDASE G = 12 EPR SIGNAL' BIOCHEMICAL SOCIETY TRANSACTIONS 19, (3) S259-S259 Author Site
Rich PR, Jeal AE, Madgwick SA & Moody AJ 1990 'Inhibitor effects on redox-linked protonations of the b haems of the mitochondrial bc1 complex' Biochim Biophys Acta 1018, (1) 29-40 Author Site
Moody AJ & Rich PR 1990 'The effect of pH on redox titrations of haem a in cyanide-liganded cytochrome-c oxidase: experimental and modelling studies' Biochim Biophys Acta 1015, (2) 205-215 Author Site
MOODY A 1989 'MITOCHONDRIAL DAMAGE AND PROTONMOTIVE STOICHIOMETRY' BIOCHEMICAL SOCIETY TRANSACTIONS 17, (5) 893-894 Author Site
MOODY A, MITCHELL R & RICH P 1989 'REDOX TITRATION OF HEME-A IN CYANIDE-LIGANDED CYTOCHROME-C OXIDASE - EFFECT OF PH' BIOCHEMICAL SOCIETY TRANSACTIONS 17, (5) 895-896 Author Site
MOODY A & RICH P 1989 'REDOX TITRATION OF HEME-A IN CYANIDE-LIGANDED CYTOCHROME-C OXIDASE - SIMULATION STUDIES ON INTERACTING, PH-DEPENDENT, REDOX CENTERS' BIOCHEMICAL SOCIETY TRANSACTIONS 17, (5) 896-897 Author Site
Moody AJ & Rich PR 1989 'The functional catalytic unit involved in proton pumping by rat liver cytochrome-c reductase and by cytochrome-c oxidase' Biochim Biophys Acta 973, (1) 29-34 Author Site
Moody AJ, Mitchell R, West IC & Mitchell P 1987 'Protonmotive stoichiometry of rat liver cytochrome c oxidase: determination by a new rate/pulse method' Biochim Biophys Acta 894, (2) 209-227 Author Site
MOODY A 1986 'IDENTIFICATION OF THE NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE OF RAT-LIVER MITOCHONDRIA' BIOCHEMICAL SOCIETY TRANSACTIONS 14, (6) 1210-1212 Author Site
Moody AJ, West IC, Mitchell R & Mitchell P 1986 'Is there Ca2+(Sr2+)-3-hydroxybutyrate symport in rat-liver mitochondria? A reappraisal' Eur J Biochem 157, (2) 243-249 Author Site
Mitchell R, West IC, Moody AJ & Mitchell P 1986 'Measurement of the proton-motive stoichiometry of the respiratory chain of rat liver mitochondria: the effect of N-ethylmaleimide' Biochim Biophys Acta 849, (2) 229-235 Author Site
West IC, Mitchell R, Moody AJ & Mitchell P 1986 'Proton translocation by cytochrome oxidase in (antimycin + myxothiazol)-treated rat liver mitochondria using ferrocyanide or hexammineruthenium as electron donor' Biochem J 236, (1) 15-21 Author Site
Mitchell P, Mitchell R, Moody AJ, West IC, Baum H & Wrigglesworth JM 1985 'Chemiosmotic coupling in cytochrome oxidase. Possible protonmotive O loop and O cycle mechanisms' FEBS Lett 188, (1) 1-7 Author Site
Moody AJ & Reid RA 1983 'Inhibition of nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles by dicyclohexylcarbodi-imide and butanedione' Biochem J 209, (3) 889-892 Author Site
Chapters
Rich PR & Moody AJ 1997 'Cytochrome c oxidase' in Gräber P; Milazzo G Bioenergetics Birkhauser 418-456
Conference Papers
Nisr RB, Moody AJ & Gilpin ML 2011 'Molecular mimicries of linear epitopes between pancreatic glutamic acid decarboxylase (GAD65) and proteins from Escherichia coli' 140-140
Dallas LJ, Shultz AD, Moody AJ, Danylchuk AJ & Sloman KA 2009 'Does the stress associated with catch-and-release angling of bonefish (Albula vulpes) affect predation by juvenile lemon sharks (Negaprion brevirostris)?' S69-S69 , DOI
Rankin HV, Moate RM, Moody AJ, MacNaughton P, Rahamim J, Smith MEF & Sneyd JR 2006 'Organ culture of human bronchial explants' 281P-282P
Shaw FL, Eggleton P, Moody AJ, Smerdon GR, Bryson PJ & Winyard P 2006 'The effect of hyperbaric oxygen on platelet S-nitrosothiol release and aggregation' S115-S115
Rankin HV, Moate RM, Moody AJ, MacNaughton P & Sneyd JR 2006 'Uneven cilial distribution in rat trachea' 281P-281P
Patel A, Moody AJ, Handy RD & Sneyd R 2001 'Carbon monoxide toxicity in the heart: evidence for ischaemia/reperfusion like injury. Joint meeting of the Biochemical Society and Physiological Society'
Handy RD, Moody AJ, Bryson P, Handy LM & Sneyd R 2001 'The effect of multiple hyperbaric oxygen treatments on blood function and redox status. Joint meeting of the Biochemical Society and Physiological Society'
Rich PR, Meunier B, Mitchell R & Moody AJ 1996 'Coupling of charge and proton movement in cytochrome c oxidase' 91-95 , DOI
Moody AJ, vonGermar F, Mantele W & Rich PR 1995 'Rapid-scan FTIR spectroscopic studies on the photolysis and recombination of the cyanide adduct of fully reduced bovine cytochrome c oxidase' S521-S521
MOODY A, RICHARDSON M & RICH P 1994 'STORAGE EFFECTS ON THE LIGAND-BINDING PROPERTIES OF BOVINE HEART CYTOCHROME-C-OXIDASE' S286-S286
Moody AJ 1991 'Ligation and electronation states of cytochrome-c oxidase in relation to other oxidases and peroxidases' ENGLAND 617-622
RICH P, MOODY A & MITCHELL R 1989 'THE CHARGE TRANSLOCATING REACTIONS OF THE BC COMPLEXES AND CYTOCHROME-OXIDASE' 7-19