Dr Kim Tieu
Associate Professor (Reader) in Clinical Neurobiology
Centre for Biomedical Research - Translational & Stratified Medicine (Peninsula Schools of Medicine and Dentistry)
2013-present Principal Investigator, Associate Professor (Reader), Department of Clinical Neurobiology, Plymouth University Peninsula Schools of Medicine and Dentistry.
2013-present Adjunct Faculty, University of Rochester (Rochester, New York).
2004-2012 Principal Investigator ( Assistant Professor) Departments of Environmental Medicine and Neurology in the Center for Translational Neuromedicine, University of Rochester (Rochester, New York).
2000-2004 Post-doctoral fellow Department of Neurology, Columbia University, New York, New York.
1995-2000 Ph.D Neuroscience, Department of Neuropsychiatry, University of Saskatchewan, Canada.
1993-2000 Pharmacist Saskatchewan, Canada
1988-1993 B.S.P. Pharmacy, College of Pharmacy,
University of Saskatchewan, Canada.
My research interest has always been to study mechanisms of neuronal dysfunction and degeneration as seen in Parkinson’s disease (PD), with the ultimate goal of developing effective therapies for this devastating neurological disorder. Our research projects address the following fundamental questions: 1) Is mitochondrial dysfunction pathogenic in PD? If so, can mitochondrial dynamics be targeted for PD treatment? 2) Glial-neuronal interactions: How do glial cells contribute to the vulnerability of dopamine neurons (the primary cell type affected in PD)? 3) Gene-environment interactions: Do mutations linked to PD render dopamine neurons more susceptible to environmental insults? To address these questions, we perform rigorous biochemical, histological, functional and genetic analyses in experimental models of PD. When applicable, post-mortem human samples are also used.