Dr Kim Tieu
Profiles

Dr Kim Tieu

Associate Professor (Reader) in Clinical Neurobiology

Centre for Biomedical Research - Translational & Stratified Medicine (Peninsula Schools of Medicine and Dentistry)

Role

2013-present   Principal Investigator, Associate Professor (Reader), Department of Clinical Neurobiology, Plymouth University Peninsula Schools of Medicine and Dentistry.

2013-present   Adjunct Faculty, University of Rochester (Rochester, New York).

Qualifications

2004-2012      Principal Investigator ( Assistant Professor)   Departments of Environmental Medicine and Neurology in the Center for Translational Neuromedicine, University of Rochester (Rochester, New York).

2000-2004      Post-doctoral fellow    Department of Neurology, Columbia University, New York, New York.

1995-2000      Ph.D                            Neuroscience, Department of Neuropsychiatry, University of Saskatchewan, Canada.

1993-2000       Pharmacist                 Saskatchewan, Canada

1988-1993      B.S.P.                          Pharmacy, College of Pharmacy,

                                                            University of Saskatchewan, Canada.

Research interests

My research interest has always been to study mechanisms of neuronal dysfunction and degeneration as seen in Parkinson’s disease (PD), with the ultimate goal of developing effective therapies for this devastating neurological disorder.  Our research projects address the following fundamental questions: 1) Is mitochondrial dysfunction pathogenic in PD? If so, can mitochondrial dynamics be targeted for PD treatment? 2) Glial-neuronal interactions: How do glial cells contribute to the vulnerability of dopamine neurons (the primary cell type affected in PD)? 3) Gene-environment interactions: Do mutations linked to PD render dopamine neurons more susceptible to environmental insults? To address these questions, we perform rigorous biochemical, histological, functional and genetic analyses in experimental models of PD. When applicable, post-mortem human samples are also used.

Journals
Articles
Tieu K & Xia XG 2014 'Cytosolic PINK1 escapes from mitochondria to promote dendritic outgrowth' J Neurochem 128, (6) 787-789 Author Site , DOI
Tieu K & Imm J 2014 'Mitochondrial Dynamics as a Potential Therapeutic Target for Parkinson’s Disease?' ADVANCES IN CLINICAL NEUROSCIENCE & REHABILITATION 14, (1) 6-8 Author Site
Jin YN, Yu YV, Gundemir S, Jo C, Cui M, Tieu K & Johnson GV 2013 'Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin' PLoS One 8, (3) Author Site , DOI
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K & Nedergaard M 2012 'Cultured astrocytes do not release adenosine during hypoxic conditions' J Cereb.Blood Flow Metab. 32, (1) e1-e7 , DOI
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K & Nedergaard M 2012 'Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity' Proc.Natl.Acad.Sci U.S.A. 109, (16) 6265-6270 , DOI
Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrane J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, Li C, Tieu K & Przedborski S 2012 'PINK1-dependent recruitment of Parkin to mitochondria in mitophagy' Proc.Natl.Acad.Sci.U.S.A. 107, (1) 378-383 , DOI
Tieu K 2011 'A Guide to Neurotoxic Animal Models of Parkinson's Disease' Cold Spring Harbor Perspective in Medicine 1, Author Site
Lim S, Chesser AS, Grima JC, Rappold PM, Blum D, Przedborski S & Tieu K 2011 'D-�-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease' PLoS ONE 6(9): e24620. doi:10.1371/journal.pone.0024620,
Rappold PM, Cui M, Chesser AS, Tibbett J, Grima JC, Duan L, Sen N, Javitch JA & Tieu K 2011 'Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3' Proc.Natl.Acad.Sci U.S.A. 108, (51) 20766-20771 , DOI
Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K & Nedergaard M 2010 'Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture' Nat.Neurosci. 13, (7) 883-888 , DOI
Rappold PM & Tieu K 2010 'Astrocytes and therapeutics for Parkinson's disease' Neurotherapeutics. 7, (4) 413-423
Cui M, Tang X, Christian WV, Yoon Y & Tieu K 2010 'Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1' J.Biol.Chem. 285, (15) 11740-11752 , DOI
Cui M, Aras R, Christian WV, Rappold PM, Hatwar M, Panza J, Jackson-Lewis V, Javitch JA, Ballatori N, Przedborski S & Tieu K 2009 'The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway' Proc.Natl.Acad.Sci.U.S.A. 106, (19) 8043-8048 , DOI
Zhou H, Falkenburger BH, Schulz JB, Tieu K, Xu Z & Xia XG 2007 'Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice' international journal of biological sciences 3, (4) 242-50
Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP, Heinecke JW & Przedborski S 2005 'Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice' J.Neurosci. 25, (28) 6594-6600 Author Site
Perier C, Tieu K, Guegan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S & Vila M 2005 'Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage' Proc.Natl.Acad.Sci.U.S.A. 102, (52) 19126-19131
Tieu K, Perier C, Vila M, Caspersen C, Zhang HP, Teismann P, Jackson-Lewis V, Stern DM, Yan SD & Przedborski S 2004 'L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease' Ann.Neurol. 56, (1) 51-60 Author Site
Tieu K, Perier C, Caspersen C, Teismann P, Wu DC, Yan SD, Naini A, Vila M, Jackson-Lewis V, Ramasamy R & Przedborski S 2003 'D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson's disease' J.Clin.Invest. 112, 892-901
Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H & Przedborski S 2002 'Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease' J.Neurosci. 22, (5) 1763-1771
Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y, Yuan CA, Rocha M, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, Burke R & Hen R 2002 'Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP' Proc.Natl.Acad.Sci.USA 99, (22) 14524-14529 Author Site
Chapters
Tolkovsky AM & Tieu K 2014 'Principles of Mitophagy and Beyond' in Autophagy (Volume 4) Elsevier 65-83
Tieu K 2006 'Mitochondrial dysfunction and neurodegenerative disorders in the basal ganglia' in Bezard E Recent Breakthroughs in Basal Ganglia Research New York Nova Science Publishers